~BeLoVeD sOnG~

Salam to all...Juz want to share my favourite song now, which I hear 3x everyday=)

I have to admit that i am a kind of easy-influenced-by-people person. So, when one of my friends introduce me this songs, i fall in love with it. Try to hear it in youtube and you'll surprise until you'l like it. Plus, it is amazing to know that it was written by an English Muslim man who has aero engineering degree=) see, who says science stream cannot do art stuff...ok,lets graps the meanings of the lyrics;

Hold My Hand-Maher Zain

I hear the flower's kinda crying loud
The breeze's sound is sad
Oh no...
Tell me when did we become
So cold and empty inside
Lost a way long time ago
Did we really turn that blind
We don't see that we keep hurting each other no
All we do is just fight

Now we share the same bright sun, the same round moon
Why don't we share the same love
Tell me why not
Life is shorter than most have thought

Hold my hand
There are many ways to do it right
Hold my hand
Turn around and see what we`ve left behind
Hold my hand my friend
We can save the good spirit of me and you
For another chance
And let's pray for a beautiful world
A beautiful world I share with you

Hold my hand....

Children seem like they've lost their smile
On the new blooded playgrounds
Oh no...
How could we ignore
heartbreaking crying sounds
And we're still going on
Like nobody really cares
And we just stopped feeling all the pain because
Like it's a daily basic affair

Now we share the same bright sun, the same round moon
Why don't we share the same love
Tell me why not
Life is shorter than most have thought

Hold my hand
There are many ways to do it right
Hold my hand
Turn around and see what we`ve left behind
Hold my hand my friend
We can save the good spirit of me and you
For another chance
And let's pray for a beautiful world
A beautiful world I share with you

No matter how far I might be
I'm always gonne be your neighbour
There's only one small planet where to be
So I'm always gonna be your neighbour
We cannot hide, we can't deny
That we're always gonna be neighbours
Your neighbour, my neighbour
We're neighbours

So hold my hand
There are many ways to do it right
Hold my hand
Turn around and see what have left behind

So hold my hand
There are many ways to do it right
Hold my hand
Turn around and see what we`ve left behind
Hold my hand my friend
We can save the good spirit of me and you
For another chance
And let's pray for a beautiful world
A beautiful world I share with you

~CADD education~

Computer-Aided Drug Design (CADD) is 1 Credit Hour-subject that I have to take in this last semester of my final year degree. This entry also is one of the assignment which need to be done as a way to promote CADD...

CADD is one of the Bioinformatics study that use computational method to stimulate drug-receptor interactions. Bioinformatics is the application of information technology and computer science in the field of Molecular Biology. Basically, it deals with analyzing, mapping, aligning and viewing 3-D protein sequences and stuctures. There are seven areas of bioinformatics that support CADD; Virtual High-Throughput Screening (vHTS), Sequence Analysis, homology modelling, similarity searches, drug lead optimization, physicochemical modelling and drug bioavailability and bioactivity.

In first class, I have been thought on searching the protein sequence of organism with ClpP and Lon A peptidase by using MEROPS...Next, similarity searches of that protein sequence and analysis is done by using BLAST...In BLAST, function of the sequence can be identified based on domain and its similarity with other organism can be known by the descriptions.MEROPS will show the peptidase that we want;

BLAST output will show you this window;


In second class, I learned on clustering using ClustalX. Clustering also known as phylogenomics. In ClustalX, known sequence can be clustered together. The clustered sequences will show more nods when they are more similar to each other in the alignment view. The view clustering genomes via Treeview will looks like this;

Besides, I learned the ARTEMIS to know the required sequences in a genome. For example, I copy and paste some of the ClpP sequence with the Lon sequence, to create a genome. Then, this ARTEMIS will provide me the location of those sequences.


In third class, I have been thought on the 3-D view of the BLAST in the Protein Data Bank (.pdb file) using RASWIN software...


All these software need to be learned from the experties theoretically and practically as its very complicated to be understood...The picture below is the example of 3D output view of RASWIN;




Theoretically,the calculation and equation on protein modelling classified into five topics;
1)Molecular mechanics
2)Molecular dynamics
3)Quantum mechanics
4)Energy minimization
5)Molecular Calculation

I love to learn CADD very much and hope that this subject will help me in my future career=)

~Life continues, Allah's bless is my highest inspiration~